Alzheimer’s-like symptoms reversed in animal study

For this study, the researchers took a look at two compounds: EGCG, or epigallocatechin-3-gallate, a key ingredient in green tea, and FA, or ferulic acid, which is found in carrots, tomatoes, rice, wheat and oats.

“After three months, combination treatment completely restored working memory and the Alzheimer’s mice performed just as well as the healthy comparison mice,” Town said.

Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town. Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice. Journal of Biological Chemistry, 2019; 294 (8): 2714 DOI: 10.1074/jbc.RA118.004280

Alzheimer disease, flavonoid, amyloid precursor protein (APP), amyloid-beta (AB), secretase, transgenic, neuroinflammation, oxidative stress, nonamyloidogenic, phenol, plant polyphenol, egcg, ferulic acid, green tea

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Tags: Alzheimer Disease, amyloid precursor protein (APP), amyloid-beta (AB), EGCG, ferulic acid, Flavonoid, Green tea, Neuroinflammation, nonamyloidogenic, Oxidative stress, phenol, plant polyphenol, secretase, transgenic