100% Cure Rate Pancreatic Cancer Experimental Study Animal Model

A research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an ‘immune memory’ in the same way that a vaccine keeps the flu away. The result is that the combination treatment also destroyed pancreatic cells that had spread to the liver, a common site for metastatic disease.

#il-12 #sbrt #pancraticcancercure

Bradley N. Mills, Kelli A. Connolly, Jian Ye, Joseph D. Murphy, Taylor P. Uccello, Booyeon J. Han, Tony Zhao, Michael G. Drage, Aditi Murthy, Haoming Qiu, Ankit Patel, Nathania M. Figueroa, Carl J. Johnston, Peter A. Prieto, Nejat K. Egilmez, Brian A. Belt, Edith M. Lord, David C. Linehan, Scott A. Gerber. Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. Cell Reports, 2019; 29 (2): 406 DOI: 10.1016/j.celrep.2019.08.095

https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31157-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112471931157X%3Fshowall%3Dtrue

Pancreatic cancer, il-12, sbrt, stereotactic body radiotherapy, pancreas, cancer, aggressive, advanced, study, CD8, treatment, immune system, vaccine, cancer vaccine, liver cancer, metastatic

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Tags: advanced, aggressive, Cancer, Cancer vaccine, CD8, il-12, Immune system, liver cancer, metastatic, Pancreas, Pancreatic cancer, sbrt, stereotactic body radiotherapy, study, Treatment, Vaccine