Probiotic LGG and Butyrate Rapidly Increase Bone Density

Probiotic LGG and Butyrate Rapidly Increase Bone Density

Probiotics increase bone volume in healthy mice

“We were surprised by the potency of the gut microbiome in regulating bone and by the complexity of the mechanism of action of probiotics,” Pacifici says. “In general, there is a lot of interest in the concept that the gut bacteria regulate the function of distant organs. How this happens is largely unknown. We described a detailed mechanism by which changes in the composition of the gut microbiome induced by probiotics affect a distant system like the skeleton.”

Immunity, Tyagi and Yu et al.: “The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression” , DOI: 10.1016/j.immuni.2018.10.013

Lactobacillus rhamnosus GG, butyrate, microbiota, bone formation, probiotics, short-chain fatty acids, Wnt10b, NFAT, T cells, regulatory T cell, bone volume, bone density, skeletal, spine

Author: Ralph Turchiano

In short, I review clinical research on an almost daily basis. What I post tends to be articles that are relevant to the readers in addition to some curiosities that have intriguing potential. As a hobby, I truly enjoy the puzzle-solving play that statistics and programming as in the python language bring to the table. I just do not enjoy problem-solving, I love problem-solving and the childlike inspiration and exploration of that innocent exhilaration of discovering something new. Enjoy ;-)