Bone, not adrenaline, drives fight or flight response

Bone, not adrenaline, drives fight or flight response

Bone, not adrenaline, drives fight or flight response

A new study from Columbia researchers suggests that bony vertebrates can’t muster this response to danger without the skeleton. The researchers found in mice and humans that almost immediately after the brain recognizes danger, it instructs the skeleton to flood the bloodstream with the bone-derived hormone osteocalcin, which is needed to turn on the fight or flight response

Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumal Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty. Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism, 2019; DOI: 10.1016/j.cmet.2019.08.012

#osteocalcin #stress #asr

https://www.sciencedirect.com/science/article/pii/S1550413119304413?via%3Dihub#fig2

Author: Ralph Turchiano

In short, I review clinical research on an almost daily basis. What I post tends to be articles that are relevant to the readers in addition to some curiosities that have intriguing potential. As a hobby, I truly enjoy the puzzle-solving play that statistics and programming as in the python language bring to the table. I just do not enjoy problem-solving, I love problem-solving and the childlike inspiration and exploration of that innocent exhilaration of discovering something new. Enjoy ;-)