Lupus strongly linked to imbalances in gut microbiome

The new study, publishing in the Annals of Rheumatic Diseases online Feb. 19, showed that 61 women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus, than 17 women of similar ages and racial backgrounds who did not have the disease and were healthy.

Alternatively, Silverman says, new treatments could also be used to promote growth of Bacteroides uniformis, bacteria thought to hinder growth of R. gnavus in the gut…..

#lupus #microbiome #Ruminococcus

Doua Azzouz, Aidana Omarbekova, Adriana Heguy, Dominik Schwudke, Nicolas Gisch, Brad H. Rovin, Roberto Caricchio, Jill P. Buyon, Alexander V. Alekseyenko, Gregg J. Silverman. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Annals of the Rheumatic Diseases, 2019; annrheumdis-2018-214856 DOI: 10.1136/annrheumdis-2018-214856

https://ard.bmj.com/content/early/2019/03/01/annrheumdis-2018-214856

Categories: Misc....

Tags: antibodies, autoimmune, Bacteria, Bacteroides uniformis, leaky gut, Lupus, Microbiome, Ruminococcus gnavus, systemic lupus erythematosus, Treatment