‘Alarmingly high’ risk of death for people with opioid use disorder in general medical care

Public Release: 24-Apr-2017

Wolters Kluwer Health

April 24, 2017 – Almost one-fifth of patients with opioid use disorder (OUD) in a large healthcare system died during a four-year follow-up period, reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published by Wolters Kluwer.

The results suggest very high rates of serious illness and death among patients with OUD in general medical care settings–much higher than for those in addiction specialty clinics, according to by Yih-Ing Hser, PhD, of University of California, Los Angeles, and colleagues. They write, “The alarmingly high morbidity and mortality among OUD patients revealed in the present study challenge healthcare systems to find new and innovative ways to expand evidence-based strategies for OUD in a variety of settings.”

Late Diagnosis and High Rates of Medical Problems for OUD Patients in Healthcare Network

Using electronic health records from their university healthcare system, the researchers identified 2,576 adults with OUD. The patients, average age 41 years at first OUD diagnosis, had high rates of physical and mental health conditions and other types of substance use disorder.

At four years of follow-up, 465 of the patients had died–a rate of 18.1 percent. Mortality in this group of patients with OUD was more than 10 times higher than in the general population, adjusted for age and sex.

About 19 percent of deaths were due to causes directly related to OUD and drug overdose. But most patients died of other causes: especially cardiovascular disease, cancer, and infectious diseases. The most common infection-related cause of death was hepatitis C virus (HCV). Because of injection drug use and other risky behaviors, people with OUD are at high risk of HCV infection.

Risk of death was even higher–twice as high for OUD patients with HCV infection. Patients with alcohol use disorder also had increased mortality.

Risk of death from cardiovascular disease was higher for patients with tobacco use disorder. Mortality from cancer was increased for patients with HCV infection, while death from liver disease was more common for patients with HCV infection and alcohol use disorder.

Previous studies have found a high risk of death among people with OUD, most commonly from drug overdose. However, most of these studies have focused on patients being treated in addiction specialty clinics or programs. One recent study found that the risk of death among patients receiving treatment for OUD was four times higher than in the general population, increasing to six times higher after they were out of treatment.

The new findings suggest a much higher risk of death for patients with OUD in general medical care. Dr. Hser and coauthors note that the patients identified in their healthcare network were older when first diagnosed with OUD, and had high rates of other physical health disorders.

Their high mortality may reflect issues with identifying and addressing OUD in the healthcare system. “It is likely that patients seen in this health system became progressively sicker, as their OUD problem was not identified until very late in its course and after physical health complications had already ensued,” the researchers write.

Within the study limitations, the results may have important implications for healthcare amid the ongoing opioid epidemic. “In the United States, healthcare providers outside specialty substance use disorders treatment settings have not traditionally been adequately equipped to identify and address patients [with] addictions,” Dr. Hser and coauthors note.

Of note, the findings do not imply that addiction treatment has worse outcomes in general health settings; the higher mortality is likely due to not receiving adequate care. The authors believe that earlier intervention might be able to reduce some of the high rates of complications and death among patients with OUD in general medical care. The authors conclude: “Further research is much needed to better engage the entire spectrum of healthcare services, with the goal of developing and delivering efficient and effective chronic care management approaches and services for OUD.”


Click here to read “High Mortality Among Patients With Opioid Use Disorder in a Large Healthcare System.”

Article: “High Mortality Among Patients With Opioid Use Disorder in a Large Healthcare System.” (doi: 10.1097/ADM.0000000000000312)

About Journal of Addiction Medicine

The mission of Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical specialty. Published six times a year, the Journal is designed for all physicians and other mental health professionals who need to keep up-to-date with the treatment of addiction disorders. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics.

About The American Society of Addiction Medicine

The American Society of Addiction Medicine (ASAM) is a professional society representing over 4,300 physicians, clinicians, and associated professionals in the field of addiction medicine. ASAM is dedicated to increasing access and improving the quality of addiction treatment, educating physicians and the public, supporting research and prevention, and promoting the appropriate role of physicians in the care of patients with addiction. Visit us on the web at http://www.ASAM.org; follow @ASAMorg on Twitter.

About Wolters Kluwer

Wolters Kluwer N.V. (AEX: WKL) is a global leader in information services and solutions for professionals in the health, tax and accounting, risk and compliance, finance and legal sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services.

Wolters Kluwer reported 2016 annual revenues of €4.3 billion. The company, headquartered in Alphen aan den Rijn, the Netherlands, serves customers in over 180 countries, maintains operations in over 40 countries and employs 19,000 people worldwide.

Wolters Kluwer shares are listed on Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).

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Categories: Lethal or Unintended Side Effects, Pharmaceutical - Medical Devices

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