Lethal or Unintended Side Effects

New insights into link between anti-cholesterol statin drugs and depression

2010 study posted for filing

Contact: Michael Bernstein m_bernstein@acs.org 202-872-6042 American Chemical Society

Scientists are reporting a possible explanation for the symptoms of anxiety and depression that occur in some patients taking the popular statin family of anti-cholesterol drugs, and reported by some individuals on low-cholesterol diets. These symptoms could result from long-term, low levels of cholesterol in the brain, the report suggests. It appears in ACS’ weekly journal Biochemistry.

Amitabha Chattopadhyay and colleagues note in the study that statins work by blocking a key enzyme involved in the body’s production of cholesterol. Some studies link the drugs to an increased risk of anxiety and depression, but the reasons are unclear. The scientists previously showed that maintaining normal cholesterol levels is important for the function of cell receptors for serotonin, a brain hormone that influences mood and behavior. But the long-term effect of cholesterol depletion on these receptors, which can occur in patients taking anti-cholesterol drugs, is unknown.

The scientists turned to the statin medication mevastatin to find out. In lab tests using human serotonin receptors expressed in animal cells, they showed that long-term use of the drug caused significant changes in the structure and function of serotonin cell receptors. Adding cholesterol to cells treated with mevastatin restored them to normal. The results represent the first report describing the effect of long-term cholesterol depletion on this type of cell receptor and suggest that chronic, low cholesterol levels in the brain might trigger anxiety and depression, the scientists say.

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ARTICLE FOR IMMEDIATE RELEASE “Chronic Cholesterol Depletion using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors”

DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/bi100276b

CONTACT: Amitabha Chattopadhyay, Ph.D. Centre for Cellular and Molecular Biology Council of Scientific and Industrial Research Hyderabad, India Phone: 91-40-2719-2578 Fax: 91-40-2716-0311 Email: amit@ccmb.res.in