COVID cases skyrocket mysteriously prior to the election while the mortality rate sharply declines

This week we look at the sharp rise in COVID-19 cases prior to the Election (Data Analytics), while mortality globally continues to naturally decline with many modern countries now reporting few to no related deaths. In addition, we pull in the Census.Gov Household Pulse Survey Data to review pandemic lockdown hardships. #covid19 #pandemic #dataanalysis Sources: covidtracking, OWID, U.S.Census

Vit. D the Most underutilized COVID tool, Low Income Households Crushed by Lockdowns, Plus Data

This week we look at how bad the lockdown is affecting low-income families, and ask why after so many months Vitamin D has been ignored. As well as Low Dose Aspirin has a powerful benefit against COVID. #aspirin #covid #lockdown Study finds over 80% of COVID-19 patients have vitamin D deficiency https://www.eurekalert.org/pub_releases/2020-10/tes-sfo102220.php#.X5ibhuBizBU.wordpress Death rates among people with severe COVID-19 drop by a half in England https://www.eurekalert.org/pub_releases/2020-10/uoe-dra102720.php#.X5iZJ_Rg_T8.wordpress New study: aspirin use reduces risk of death in hospitalized patients https://www.eurekalert.org/pub_releases/2020-10/uoms-nsa102220.php https://www.census.gov/data-tools/demo/hhp/#/?measures=EVR

Vitamin D may be more effective than masks and distancing combined for COVID ?

Vitamin D may be more effective than masks and distancing combined for COVID ?

In patients older than 40 years they observed that those patients who were vitamin D sufficient were 51.5 percent less likely to die from the infection compared to patients who were vitamin D deficient or insufficient with a blood level of 25-hydroxyvitamin D less than 30 ng/mL.

Holick, who most recently published a study which found that a sufficient amount of vitamin D can reduce the risk of catching coronavirus by 54 percent, believes that being vitamin D sufficient helps to fight consequences from being infected not only with the corona virus but also other viruses causing upper respiratory tract illnesses including influenza. “There is great concern that the combination of an influenza infection and a coronal viral infection could substantially increase hospitalizations and death due to complications from these viral infections.”

#covid19 #sarscov2 #vitaminD

Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF (2020) SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLOS ONE 15(9): e0239252. https://doi.org/10.1371/journal.pone.0239252

Vitamin D twice a day may keep vertigo away

Those in the intervention group who took the supplements had a lower recurrence rate for vertigo episodes after an average of one year than those in the observation group. People taking supplements had an average recurrence rate of 0.83 times per person-year, compared to 1.10 times per person-year for those in the observation group, or a 24% reduction in the annual recurrence rate.

#vertigo #bppv #vitamind

Seong-Hae Jeong, Ji-Soo Kim, Hyo-Jung Kim, Jeong-Yoon Choi, Ja-Won Koo, Kwang-Dong Choi, Ji-Yun Park, Seung-Han Lee, Seo-Young Choi, Sun-Young Oh, Tae-Ho Yang, Jae Han Park, Ileok Jung, Soyeon Ahn, Sooyeon Kim. Prevention of Benign Paroxysmal Positional Vertigo with Vit D Supplementation: A Randomized Trial. Neurology, 2020; DOI: 10.1212/WNL.0000000000010343

https://n.neurology.org/content/95/9/e1117

Vertigo, bppv, Benign paroxysmal positional vertigo, Vitamin d, dizziness, spinning, balance, 20 nanograms per milliliter, common, intervention, treatment

COVID-19 Updated Nutritional Supplement Research

COVID-19 Updated Nutritional Supplement Research

Dietary supplements an important weapon for fighting off COVID-19

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections Nutrients 2020, 12(4), 1181; https://doi.org/10.3390/nu12041181

https://www.mdpi.com/2072-6643/12/4/1181/htm

Ayurveda and yoga for COVID-19 prevention

Public Health Approach of Ayurveda and Yoga for COVID-19 Prophylaxis Published Online:20 Apr 2020https://doi.org/10.1089/acm.2020.0129

https://www.liebertpub.com/doi/10.1089/acm.2020.0129

#Ashwagandha, #Dietarysupplements, #sars-cov-2

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775

https://jamanetwork.com/journals/jama/fullarticle/2765184?guestAccessKey=906e474e-0b94-4e0e-8eaa-606ddf0224f5

Eurekalet

https://www.eurekalert.org/

Science Daily

https://www.sciencedaily.com/

Annals of Internal Medicine

https://annals.org/

Ayurveda, sars-cov-2, yoga, dietary supplements, immune system, , dosage, zinc, omega-3, dha, epa, nutritional status, mechanical ventilator, mortality, vitamin e, SARS coronavirus 2, Prophylaxis, immune system; viral infection; influenza; COVID-19; micronutrients, vitamins, omega-3 fatty acids, minerals, vitamin C, vitamin D, influenza, flu, virus,

COVID-19 STRONG CORRELATION WITH VITAMIN D DEFICIENCY

COVID-19 STRONG CORRELATION WITH VITAMIN D DEFICIENCY

In conclusion, we found significant relationships between vitamin D levels and the number COVID–19 cases and especially the mortality caused by this infection. The most vulnerable group of population for COVID–19 is also the one that has the most deficit in Vitamin D.

**Physical Distance NOT Social Distance Commentary

#vitaminD #covid19 #sarscov2

The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality DOI:10.21203/rs.3.rs-21211/v1

https://www.researchsquare.com/article/rs-21211/v1

COVID-19: Genetic network analysis provides ‘snapshot’ of pandemic origin

https://www.eurekalert.org/pub_releases/2020-04/uoc-cgn040820.php#.XpOpCYt69MY.wordpress

Vitamin D deficiency in Ireland– implications for COVID-19.Results from The Irish Longitudinal Study on Ageing (TILDA)

https://tilda.tcd.ie/publications/reports/pdf/Report_Covid19VitaminD.pdf

The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents

https://www.ifm.org/news-insights/the-functional-medicine-approach-to-covid-19-virus-specific-nutraceutical-and-botanical-agents/

Researchers find low magnesium levels make vitamin D ineffective

https://www.eurekalert.org/pub_releases/2018-02/aoa-rfl022318.php

https://www.youtube.com/watch?v=MfLJkzkDpfU&t=1s

Suicide Mortality and Coronavirus Disease 2019—A Perfect Storm?

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2764584?widget=personalizedcontent&previousarticle=2764583

covid-19, sars-cov-2, vitamin d, status, treatment, prevention, deficiency, elderly, susceptibility, d2, d3, relationship d covid-19, covid-19 a, covid-19 b, covid-19 c, magnesium , Coronavirus, sar, cov

Bone mineral density increased 4.8% in 12 months with MSDK

Bone mineral density increased 4.8% in 12 months with MSDK

Bone mineral density increased 4.8% in 12 months with MSDK

This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%)

Maria S, Swanson MH, Enderby LT, et al. Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures. Aging (Albany NY). 2017;9(1):256-285.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310667/

High Vitamin D Levels associated with an 82% reduction in Breast Cancer Incidence

High Vitamin D Levels associated with an 82% reduction in Breast Cancer Incidence

High Vitamin D Levels associated with an 82% reduction in Breast Cancer Incidence

“We found that participants with blood levels of 25(OH)D that were above 60 ng/ml had one-fifth the risk of breast cancer compared to those with less than 20 ng/ml,” said principal investigator and co-author Cedric F. Garland, DrPH, adjunct professor in the UC San Diego Department of Family Medicine and Public Health. Risk of cancer appeared to decline with greater levels of serum vitamin D.

Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort McDonnell SL, Baggerly CA, French CB, Baggerly LL, Garland CF, et al. (2018) Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PLOS ONE 13(6): e0199265. https://doi.org/10.1371/journal.pone.0199265

Low magnesium levels make vitamin D ineffective

Low magnesium levels make vitamin D ineffective

Low magnesium levels make vitamin D ineffective

A review published in The Journal of the American Osteopathic Association found Vitamin D can’t be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans

Citation: Role of Magnesium in Vitamin D Activation and Function, The Journal of the American Osteopathic Association, March 2018, Vol. 118, 181-189. doi:10.7556/jaoa.2018.037

Arterial Stiffness Rapidly reduced with high dose Vitamin D

Arterial Stiffness Rapidly reduced with high dose Vitamin D

Researchers witness a 10.4% reduction in arterial stiffness in just 16 weeks with high dose oral vitamin D.
Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424

Vitamin Wars – Will keep posted till the end of February 2014

EEV: Video posted here at request – That’s me So Don’t Troll me Bro 😉

Brief Commentary in regards to the Dr. OZ show and his upcoming guest. Discusses the plea that we need to stop relying on those who do not present facts to back up their outrageous claims. In addition to recognize, that we the public are being ignored by all sides in a quest for unbiased knowledge.

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Health Research Report #170 14 DEC 2013

Health Research Report

#170

Latest Health Research Report Click Image for Report
 

14 DEC 2013 /  White paper draft

Compiled by Ralph Turchiano

 

Detailed research references and further affiliations on each article are posted at www.healthreserachreport.me .

 

In this Issue:

1.       Evidence suggests that “healthy and overweight” is a myth
2.       Vitamin D Decreases Pain in Women with Type 2 Diabetes and Depression
3.       Estrogen: Not just produced by the ovaries
4.       Eating healthy vs. unhealthy diet costs about $1.50 more per day
5.       Progesterone changes may cause cognitive impairment of Alzheimer’s disease patients
6.       Does zinc supplementation reduce aluminum-induced neurotoxicity?
7.       Researchers see added nutritional benefits in organic milk
8.       You are what your father eats
9.       Long-term use of common heartburn and ulcer medications linked to vitamin B12 deficiency
10.   Gut microbes affect MicroRNA response to bacterial infection
11.   Low vitamin B12 levels increase the risk of fractures in older men
12.   Dietary amino acids relieve sleep problems after traumatic brain injury in animals
13.   Personal care products are possible sources of potentially harmful parabens for babies
14.   New study shows link between perfluorinated compounds and diabetes Continue reading “Health Research Report #170 14 DEC 2013”

Vitamin D Decreases Pain in Women with Type 2 Diabetes and Depression

Continue reading “Vitamin D Decreases Pain in Women with Type 2 Diabetes and Depression”

The Counter to the Lancet Claims Vitamin D has little Efficay – Well the Lancet is mistaken ( Here, try some Science )

For the very non scientific claims of Vitamin D lacking evidence, as posted in other publications like the Mail onlie:

Vitamin D supplements ‘don’t ward off ill health’: Little evidence pills lower risk of cancer, strokes or other conditions

Here are small snipets of data to unhinge experimenter bias and media misconceptions:

MS reversed in mice / Single dose  ( Calcitriol ) Vitamin D followed by Vitamin D supplements

Vitamin D reduces blood pressure and relieves depression in women with diabetes

Vitamin D supplementation may delay precocious puberty in girls

Vitamin D deficiency may help spread of hepatitis B throughout liver

Preterm infants may need 800 IU of vitamin D3 per day

Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis

Vitamin D may reduce risk of uterine fibroids, according to NIH study

Vitamin D proven to boost energy — from within the cells

Experts find link between low doses of vitamin D and adverse pregnancy outcomes

Vitamin D benefits breathing in tuberculosis patients

Study reveals potential immune benefits of vitamin D supplements in healthy individuals

Vitamin D, omega-3 may help clear amyloid plaques found in Alzheimer’s

Low vitamin D levels may increase risk of Type 1 diabetes: Up to 50%

Vitamin D Holds Promise in Battling a Deadly Breast Cancer, SLU Researchers Say

New review associates vitamin D with lower rates of tooth decay

Researchers recommend pregnant women take 4,000 IU vitamin D a day

Vitamin D, may protect us from background radiation and could be used as a safe protective agent before or after a low-level nuclear incident

Gestational exposure to urban air pollution linked to vitamin D deficiency in newborns

Could vitamin D, a key milk nutrient, affect how you age?

Vitamin D deficiency: Common and problematic yet preventable

* Alright I can’t post all the research titles over the past 7  years, since just the titles alone are over 35 pages…. You are welcome to search for far more 😉

Sincerely,

Ralph Tutchiano

Most ignored medical breakthroughs ( Part 1 ) Please share or Repost Freely

This is part 1 of the most ignored medical breakthroughs since I started accumulating research. There is far more research that never made any of the major media outlets. Healthcare does not need to be scary nor expensive if science not profit were held in a higher esteem.

Please share this list…It can make a significant difference in more ways than one.. 😉

Ralph Turchiano

 

MS reversed in mice / Single dose ( Calcitriol ) Vitamin D followed by Vitamin D supplements

Contact: Colleen Hayes cehayes@wisc.edu 608-263-6387 University of Wisconsin-Madison

Mouse studies reveal promising vitamin D-based treatment for MS

MADISON — A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

Many people with MS start using some kind of mobility aid — cane, walker, scooter or wheelchair — by 45 or 50, and those with the most severe cases are typically bed-bound by 60. The medications that are currently available don’t do much to slow the relentless march of the disease.

In search of a better option for MS patients, a team of University of Wisconsin-Madison biochemists has discovered a promising vitamin D-based treatment that can halt — and even reverse — the course of the disease in a mouse model of MS. The treatment involves giving mice that exhibit MS symptoms a single dose of calcitriol, the active hormone form of vitamin D, followed by ongoing vitamin D supplements through the diet. The protocol is described in a scientific article that was published online in August in the Journal of Neuroimmunology.

“All of the animals just got better and better, and the longer we watched them, the more neurological function they regained,” says biochemistry professor Colleen Hayes, who led the study.

MS afflicts around 400,000 people nationwide, with 200 new cases diagnosed each week. Early on, this debilitating autoimmune disease, in which the immune system attacks the myelin coating that protects the brain’s nerve cells, causes symptoms including weakness, loss of dexterity and balance, disturbances to vision, and difficulty thinking and remembering. As it progresses, people can lose the ability to walk, sit, see, eat, speak and think clearly.

Current FDA-approved treatments only work for some MS patients and, even among them, the benefits are modest. “And in the long term they don’t halt the disease process that relentlessly eats away at the neurons,” Hayes adds. “So there’s an unmet need for better treatments.”

While scientists don’t fully understand what triggers MS, some studies have linked low levels of vitamin D with a higher risk of developing the disease. Hayes has been studying this “vitamin D hypothesis” for the past 25 years with the long-term goal of uncovering novel preventive measures and treatments. Over the years, she and her researchers have revealed some of the molecular mechanisms involved in vitamin D’s protective actions, and also explained how vitamin D interactions with estrogen may influence MS disease risk and progression in women.

In the current study, which was funded by the National Multiple Sclerosis Society, Hayes’ team compared various vitamin D-based treatments to standard MS drugs. In each case, vitamin D-based treatments won out. Mice that received them showed fewer physical symptoms and cellular signs of disease.

First, Hayes’ team compared the effectiveness of a single dose of calcitriol to that of a comparable dose of a glucocorticoid, a drug now administered to MS patients who experience a bad neurological episode. Calcitriol came out ahead, inducing a nine-day remission in 92 percent of mice on average, versus a six-day remission in 58 percent for mice that received glucocorticoid.

“So, at least in the animal model, calcitriol is more effective than what’s being used in the clinic right now,” says Hayes.

Next, Hayes’ team tried a weekly dose of calcitriol. They found that a weekly dose reversed the disease and sustained remission indefinitely.

But calcitriol can carry some strong side effects — it’s a “biological sledgehammer” that can raise blood calcium levels in people, Hayes says — so she tried a third regimen: a single dose of calcitriol, followed by ongoing vitamin D supplements in the diet. This one-two punch “was a runaway success,” she says. “One hundred percent of mice responded.”

Hayes believes that the calcitriol may cause the autoimmune cells attacking the nerve cells’ myelin coating to die, while the vitamin D prevents new autoimmune cells from taking their place.

While she is excited about the prospect of her research helping MS patients someday, Hayes is quick to point out that it’s based on a mouse model of disease, not the real thing. Also, while rodents are genetically homogeneous, people are genetically diverse.

“So it’s not certain we’ll be able to translate (this discovery to humans),” says Hayes. “But I think the chances are good because we have such a broad foundation of data showing protective effects of vitamin D in humans.”

The next step is human clinical trials, a step that must be taken by a medical doctor, a neurologist. If the treatment works in people, patients with early symptoms of MS may never need to receive an official diagnosis.

“It’s my hope that one day doctors will be able to say, ‘We’re going to give you an oral calcitriol dose and ramp up the vitamin D in your diet, and then we’re going to follow you closely over the next few months. You’re just going to have this one neurological episode and that will be the end of it,'” says Hayes. “That’s my dream.”

###

 

Nicole Miller nemiller2@wisc.edu 608-262-3636

158th Health Research Report Synopsis 28 JUN 2013

Posted at www.healthresearchreport.me 

VH Stores Alt Emblem

Health Research Report

158th Issue Date 28 JUN 2013

Compiled By Ralph Turchiano

www.vit.bz

www.youtube.com/vhfilm

 www.facebook.com/engineeringevil

www.healthresearchreport.me 

In this Issue:

  1. Dietary supplement linked to increased muscle mass in the elderly
  2. Vitamin D supplementation may delay precocious puberty in girls
  3. Artificial Sweetener a Potential Treatment for Parkinson’s Disease
  4. Iodine in bread not enough for pregnant women
  5. Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds
  6. Nearly 7 in 10 Americans Take Prescription Drugs, Mayo Clinic, Olmsted Medical Center Find
  7. Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels
  8. Dietary fructose causes liver damage in animal model, study finds
  9. Daily iron during pregnancy linked to improved birth weight
  10. Vitamin D reduces blood pressure and relieves depression in women with diabetes
  11. UT study: Chemical in antibacterial soaps may harm nursing babies

152 Health Research Report Topics Post 5 APR 2013

VH Stores Alt Emblem

Health Research Report

152nd Issue Date 5 Apr 2013

Compiled By Ralph Turchiano

www.vit.bz

www.youtube.com/vhfilm

 www.facebook.com/engineeringevil

www.healthresearchreport.me 

120922_0002

In this Issue:

  1. Higher soy intake prior to lung cancer diagnosis linked to longer survival in women
  2. Experts find link between low doses of vitamin D and adverse pregnancy outcomes
  3. C. diff infection risk rises with antihistamine use to treat stomach acid, Mayo Clinic finds
  4. Nothing fishy about it: Fish oil can boost the immune system
  5. Eating fish associated with lower risk of dying among older adults
  6. Verifying that sorghum is a new safe grain for people with celiac disease
  7. Dental anesthesia may interrupt development of wisdom teeth in children
  8. Vitamin D proven to boost energy — from within the cells

 

 

VH Stores Alt Emblem

Health Research Report

152nd Issue Date 5 Apr 2013

Compiled By Ralph Turchiano

www.vit.bz

www.youtube.com/vhfilm

 www.facebook.com/engineeringevil

www.healthresearchreport.me 

120922_0002

Panel Recommends ***Against*** Daily Vitamin D and Calcium Supplementation for the Primary Prevention of Fractures in Postmenopausal Women

EEV: I had to read the title a few times. They claim that 1 kidney stone per 273 woman over seven years is to great a risk. 2.5% Sup group vs. 2.1 Placebo Group. Hmmmm. I recommend that this taskforce immediately eliminate Vitamin D and Calcium from their diets, to avoid any future possible risk of a kidney stone…In addition to being the healthy  nutrient deficient control group this world desperately needs to see.

Contact: Megan Hanks mhanks@acponline.org 215-351-2656 American College of Physicians

Annals of Internal Medicine tip sheet for Feb. 26, 2013

Embargoed news from Annals of Internal Medicine

1.

The United States Preventive Services Task Force recommends against daily supplementation with doses of vitamin D ≤ 400 IU and calcium ≤ 1,000 mg for the primary prevention of fractures in postmenopausal women living in the community setting. The Task Force found insufficient evidence to assess the benefits and harms of daily supplementation with higher doses in this population. Evidence also was insufficient to recommend for or against daily vitamin D and calcium supplementation to prevent fractures in premenopausal women or in men. Fracture prevention in older patients is important because fractures (especially hip fractures) are associated with chronic pain, disability, and increased mortality. One half of all postmenopausal women will have an osteoporosis-related fracture in their lifetime. Vitamin D and calcium supplements are inexpensive and readily available without a prescription. To form a recommendation, the Task Force commissioned two systematic evidence reviews and a meta-analysis on vitamin D supplementation with or without calcium. Researchers reviewed the evidence to assess the effects of vitamin D and calcium on bone health outcomes in community-dwelling adults and the adverse effects of supplementation. Based on the evidence, researchers concluded with moderate certainty that daily supplementation with doses of vitamin D ≤ 400 IU and calcium ≤ 1,000 mg has no net benefit for the primary prevention of fractures, and that it increases the incidence of kidney stones. The recommendation applies to nonistitutionalized, asymptomatic adults without previous history of fractures. In previous recommendations related to fracture prevention, the Task Force recommended screening for osteoporosis in women age 65 or older and in younger women at high risk for fracture. The Task force also recommends vitamin D supplementation to prevent falls in community-dwelling adults age 65 and older who are at increased risk for falls. Task force evidence reviews and recommendation statements can be found at www.annals.org.

Note: For an embargoed PDF, please contact Megan Hanks or Angela Collom. To speak with the author, please contact Ana Fullmer at ana.fullmer@edelman.com or 202-350-6668

Nearly 80 Million Americans Won’t Need Vitamin D Supplements Under New Guidelines

Engineering Evil: There is Absolutely No Current Solid Scientific Basis for the IOM’s recommendation:

  • Current guidelines
  • Normal: equal to or greater than 32 nanograms per milliliter (ng/mL)
  • Insufficient: less than 32 ng/mL
  • Deficient: less than 20 ng/mL
  • When Vitamin D levels in the bloodstream is at or less than 20 ng/ml the bone starts to become brittle in adults and in kids it causes rickets
  • Instead of attempting to improve the nutrient profile of the public. The IOM just dropped the numbers in order to claim success.
  • The IOM claims their opinion is based upon 1000 published studies. They are either not recent studies, or there are other negative issues.

Now Please continue reading at your own risk

ScienceDaily (Oct. 24, 2012) — Nearly 80 million Americans would no longer need to take vitamin D supplements under new Institute of Medicine guidelines, according to a study by Loyola University Chicago Stritch School of Medicine researchers.

Results were published Oct. 24, 2012 in the journal PLOS ONE.

The new guidelines advise that almost all people get sufficient vitamin D when their blood levels are at or above 20 nanograms per milliliter (ng/ml). Older guidelines said people needed vitamin D levels above 30 ng/ml.

Holly Kramer, MD, MPH and colleagues examined data from 15,099 non-institutionalized adults who participated in the Third National Health and Nutrition Examination Study (NHANES III). The sample included 1,097 adults who had chronic kidney disease, which has been linked to low vitamin D levels.

In the survey population, 70.5 percent of adults with healthy kidneys had vitamin D blood levels that would be considered insufficient under the older guidelines. But under the newer Institute of Medicine guidelines, only 30.3 percent of these adults had insufficient vitamin D levels.

Among adults with chronic kidney disease, 76.5 percent had insufficient vitamin D under the older guidelines, while only 35.4 percent had insufficient levels under the Institute of Medicine guidelines.

Because NHANES III is a representative sample, researchers were able to extrapolate results to the general population. Kramer and colleagues estimate that a total of 78.7 million adults considered to have insufficient vitamin D levels under the older guidelines would now have sufficient levels under the Institute of Medicine guidelines. “The new guidelines have an impact on a large proportion of the population,” Kramer said.

The Institute of Medicine guidelines are based on nearly 1,000 published studies and testimony from scientists and other experts. (The Institute of Medicine committee that wrote the new guidelines for vitamin D and calcium includes Ramon Durazo-Arvizu, PhD, a professor in Loyola’s Department of Preventive Medicine and Epidemiology).

The Institute of Medicine committee found that vitamin D is essential to avoid poor bone health, such as rickets. But there have been conflicting and mixed results in studies on whether vitamin D can also protect against cancer, heart disease, autoimmune diseases and diabetes, the Institute of Medicine committee found. Moreover, excessive vitamin D can damage the kidneys and heart, the committee reported.

However, the Institute of Medicine guidelines are controversial. For example, the Endocrine Society continues to endorse the older guidelines. Kramer said that people who are confused about how much vitamin D they need should consult with their doctors.

Kramer is first author of the study, which was funded by the National Institutes of Health. She is an associate professor in Loyola’s Department of Preventive Medicine and Epidemiology and Department of Medicine, Division of Nephrology and Hypertension. Her co-authors are Durazo-Arvizu; Guichan Cao, MS; Amy Luke, PhD; David Shoham, PhD; and Richard Cooper, PhD of Loyola’s Department of Preventive Medicine and Epidemiology and Chris Sempos, PhD of the National Institutes of Health’s Office of Dietary Supplements

Human lung tumors destroy anti-cancer hormone vitamin D, Pitt researchers find

2009 study posted for filing

Contact: Courtney McCrimmon
McCrimmonCP@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences

DENVER, Colo., April 20 – Human lung tumors have the ability to eliminate Vitamin D, a hormone with anti-cancer activity, a new study from the University of Pittsburgh Cancer Institute (UPCI) suggests. Results of the study, Abstract Number 2402, are being presented at the 100th annual meeting of the American Association for Cancer Research (AACR), April 18 to 22, in Denver.

“High levels of Vitamin D help the body produce proteins with anti-tumor activity,” explained principal investigator Pamela Hershberger, Ph.D., a research assistant professor in UPCI’s Department of Pharmacology and Chemical Biology. “We’ve discovered that lung cancer cells make an enzyme called CYP24, which counteracts the positive effects of Vitamin D. To better study it, we developed the first radioactive-free assay that measures the amount of Vitamin D in tissues and blood.”

According to Dr. Hershberger, this test is sensitive enough to have clinical potential. “We hope this new assay will help identify the best approaches to maintain therapeutic levels of Vitamin D in tissues,” she said.

Lung cancer is the leading cause of cancer death in the United States in both men and women, killing 160,000 people annually, and remains one of the most difficult cancers to treat. The five-year survival rate remains low, and better treatments are much needed. According to Dr. Hershberger, it is possible that one day Vitamin D could be used as a chemopreventive agent to improve patient outcomes.

 

###

 

This study was supported by UPCI’s Lung Cancer Specialized Program of Research Excellence.

Founded in 1984, the University of Pittsburgh Cancer Institute became a National Cancer Institute (NCI)-designated Comprehensive Cancer Center in record time, six years. UPCI, the only cancer center in western Pennsylvania with this elite designation, serves the region’s population of more than 6 million. Presently, UPCI receives a total of $154 million in research grants and is ranked 10th in funding from the

Vitamin D, may protect us from background radiation and could be used as a safe protective agent before or after a low-level nuclear incident

2008 study re-posted for filing

Contact: Daniel Hayes
dhayes@health.nyc.gov
Inderscience Publishers

Could vitamin D save us from radiation?

Radiological health expert Daniel Hayes, Ph.D., of the New York City Department of Health and Mental Hygiene suggests that a form of vitamin D could be one of our body’s main protections against damage from low levels of radiation. Writing in the International Journal of Low Radiation, Hayes explains that calcitriol, the active form of vitamin D, may protect us from background radiation and could be used as a safe protective agent before or after a low-level nuclear incident.

Biologists and pharmacologists who specialize in radiation and health are keen to find an effective agent that could be given by mouth, have few side effects and would protect us against a suspected or impending nuclear event, whether an accident, terrorist attack, or other incident.

In terms of protecting people from the long-term effects of radiation, cancer formation would be the main focus. The ideal agent would act by blocking DNA damage or by halting the progression of damaged cells that might eventually grow into cancers.

While a drug is yet to be found with such ideal radio-protective properties, other researchers have demonstrated that certain dietary supplements have at least some of the desired properties. Hayes argues that vitamin D, and in particular its biologically active form, could be the key ingredient in radiological protection.

“Our general understanding and appreciation of the multifaceted protective actions of vitamin D have recently entered a new era,” says Hayes, “It is now becoming recognized that its most active molecular form, 1,25-dihydroxyvitamin D3, may offer protection against a variety of radiation- and otherwise-induced damages.”

Hayes has reviewed the various biochemical mechanisms by which vitamin D protects users_ from the low levels of natural radiation released by the rocks on which we stand and the skies above us. He points out that calcitriol is involved in cell cycle regulation and control of proliferation, cellular differentiation and communication between cells, as well as programmed cell death (apoptosis and autophagy) and antiangiogenesis.

Calcitriol is the form of vitamin D that activates the body’s Vitamin D Receptor (VDR), which allows gene transcription to take place and the activation of the innate immune response.

It is possible that several of the transcribed by the VDR will help transcribe proteins that protect the body against radiation.

“Vitamin D by its preventive/ameliorating actions should be given serious consideration as a protective agent against sublethal radiation injury, and in particular that induced by low-level radiation,” concludes Hayes.

Cod liver oil outperforms standard drugs for tuberculosis

Could cod liver oil help combat tuberculosis?

Repost from Dec 2011

A review of a historical study from 1848 reveals that cod liver oil was an effective treatment for tuberculosis, says Professor Sir Malcolm Green in the Christmas issue published on bmj.com today.

In the study, carried out by physicians at the Hospital for Consumption, Chelsea (now the Royal Brompton Hospital), 542 patients with consumption (tuberculosis) received standard treatment with cod liver oil. These patients were compared with 535 ‘control’ patients who received standard treatment alone (without cod liver oil).

While improvement rates were similar in the two groups, the disease was stabilised in 18% of the patients given cod liver oil, compared with only 6% of those in the control group. Deterioration or death occurred in 33% of patients given standard treatment alone, but in only 19% of those given cod liver oil, a reduction of 14%.

Professor Green says that some children are still given cod liver oil today and perhaps this relates back to the late 19th and early 20th centuries when cod liver oil was widely used to treat and prevent tuberculosis.

He adds that the steady fall in tuberculosis deaths in the late 19th and early 20th centuries is often attributed to better living conditions. While a reduction in overcrowded living might have reduced transmission, Green believes improved nutrition was probably as important. “It could well be that the widespread use of cod liver oil encouraged by doctors played a significant part,” he writes.

Cod liver oil is a rich source of Vitamin D, which we now know is important in fighting infections, as well as preventing conditions such as rickets, says the author.

He says: “A role for vitamin D in combating tuberculosis gives a rational basis for sunshine therapy, which was widely practised for patients in sanatoriums before chemotherapy became available, as vitamin D is synthesised in the skin when exposed to the sun. Patients were put out on their beds to lie in the sun in summer and winter, and many were sent to Switzerland and other sunny countries for treatment.”  He adds that today many patients who develop TB in the UK are found to be Vitamin D deficient.

Green concludes that since tuberculosis is still a common infection, accounting for  millions of deaths annually across the world, there may yet be a role for vitamin D supplements in combating this terrible killer.