Serine Shows Promise for Alzheimer’s and ALS

Serine Shows Promise for Alzheimer’s and ALS

Scientists have also demonstrated that memorization functions in mice were restored by supplying nutritional L-serine.

#serine #alzheimers #als

Juliette Le Douce, Marianne Maugard, Julien Veran, Marco Matos, Pierrick Jégo, Pierre-Antoine Vigneron, Emilie Faivre, Xavier Toussay, Michel Vandenberghe, Yaël Balbastre, Juliette Piquet, Elvire Guiot, Nguyet Thuy Tran, Myriam Taverna, Stéphane Marinesco, Ayumi Koyanagi, Shigeki Furuya, Mylène Gaudin-Guérif, Sébastien Goutal, Aurélie Ghettas, Alain Pruvost, Alexis-Pierre Bemelmans, Marie-Claude Gaillard, Karine Cambon, Lev Stimmer, Véronique Sazdovitch, Charles Duyckaerts, Graham Knott, Anne-Sophie Hérard, Thierry Delzescaux, Philippe Hantraye, Emmanuel Brouillet, Bruno Cauli, Stéphane H.R. Oliet, Aude Panatier, Gilles Bonvento. Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s DiseaseCell Metabolism, 2020; 31 (3): 503 DOI: 10.1016/j.cmet.2020.02.004

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413120300632%3Fshowall%3Dtrue

The addition of dietary L-serine, a naturally occurring amino acid necessary for formation of proteins and nerve cells, delayed signs of amyotrophic lateral sclerosis (ALS) in an animal study.

Deborah C Mash, Walter G Bradley, Amy Beierschmitt, Roberta M Palmour, James S Metcalf, James T Powell, Matthew J Hagan, Susanna P Garamszegi, Patricia D Lecusay, Sandra Anne Banack, Paul Alan Cox, David A Davis. l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MNDJournal of Neuropathology & Experimental Neurology, 2020; DOI: 10.1093/jnen/nlaa002

https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlaa002/5740037

Mannose impairs tumour growth and enhances chemotherapy

Mannose impairs tumour growth and enhances chemotherapy

Mannose impairs tumour growth and enhances chemotherapy

Tumours use more glucose than normal, healthy tissues. However, it is very hard to control the amount of glucose in your body through diet alone. In this study, the researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use*.

Pablo Sierra Gonzalez et al, Mannose impairs tumour growth and enhances chemotherapy, Nature (2018). DOI: 10.1038/s41586-018-0729-3

Tumor, tumours, cancer, mannose, d-mannose, sugar, glucose, energy

Blood Sugar Lowered Dramatically with AMPK Raising Alanine

Blood Sugar Lowered Dramatically with AMPK Raising Alanine

Blood Sugar Lowered Dramatically with AMPK Raising Alanine

Type 2 diabetes is driven by many metabolic pathways, with some pathways driven by amino acids, the molecular building blocks for proteins. Scientists at Joslin Diabetes Center now have shown that one amino acid, alanine, may produce a short-term lowering of glucose levels by altering energy metabolism in the cell.

Yusuke Adachi, Ana Luisa De Sousa-Coelho, Ikue Harata, Charlie Aoun, Sandra Weimer, Xu Shi, Karina N. Gonzalez Herrera, Hirokazu Takahashi, Chris Doherty, Yasushi Noguchi, Laurie J. Goodyear, Marcia C. Haigis, Robert E. Gerszten, Mary-Elizabeth Patti. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Molecular Metabolism, 2018; DOI: 10.1016/j.molmet.2018.08.002

AMPK, TYPE 2 Diabetes, alanine, glucose, insulin, Adenosine monophosphate-activated protein kinase, energy, glucose tolerance, ala, Krebs cycle, diabetes,

Sugar helps cancer cells regulate voltage

Sugar helps cancer cells regulate voltage

Sugar helps cancer cells regulate voltage

Researchers in an attempt to understand why Cancers will hold onto sugar yet not use it as fuel discovered that Cancer Cells use sugar as a sort of voltage regulator.

1. Ca2 -dependent demethylation of phosphatase PP2Ac promotes glucose deprivation–induced cell death independently of inhibiting glycolysis. Science Signaling, 2018; 11 (512): eaam7893 DOI: 10.1126/scisignal.aam7893