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Serine Shows Promise for Alzheimer’s and ALS

By Ralph Turchiano on March 18, 2020

Scientists have also demonstrated that memorization functions in mice were restored by supplying nutritional L-serine.

#serine #alzheimers #als

Juliette Le Douce, Marianne Maugard, Julien Veran, Marco Matos, Pierrick Jégo, Pierre-Antoine Vigneron, Emilie Faivre, Xavier Toussay, Michel Vandenberghe, Yaël Balbastre, Juliette Piquet, Elvire Guiot, Nguyet Thuy Tran, Myriam Taverna, Stéphane Marinesco, Ayumi Koyanagi, Shigeki Furuya, Mylène Gaudin-Guérif, Sébastien Goutal, Aurélie Ghettas, Alain Pruvost, Alexis-Pierre Bemelmans, Marie-Claude Gaillard, Karine Cambon, Lev Stimmer, Véronique Sazdovitch, Charles Duyckaerts, Graham Knott, Anne-Sophie Hérard, Thierry Delzescaux, Philippe Hantraye, Emmanuel Brouillet, Bruno Cauli, Stéphane H.R. Oliet, Aude Panatier, Gilles Bonvento. Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease. Cell Metabolism, 2020; 31 (3): 503 DOI: 10.1016/j.cmet.2020.02.004

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413120300632%3Fshowall%3Dtrue

The addition of dietary L-serine, a naturally occurring amino acid necessary for formation of proteins and nerve cells, delayed signs of amyotrophic lateral sclerosis (ALS) in an animal study.

Deborah C Mash, Walter G Bradley, Amy Beierschmitt, Roberta M Palmour, James S Metcalf, James T Powell, Matthew J Hagan, Susanna P Garamszegi, Patricia D Lecusay, Sandra Anne Banack, Paul Alan Cox, David A Davis. l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND. Journal of Neuropathology & Experimental Neurology, 2020; DOI: 10.1093/jnen/nlaa002

https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlaa002/5740037