We are led to question whether the recommended social distancing measures to prevent SARS-CoV-2 transmission could increase the number of other serious instabilities. The breaking of the contagion pathways reduces the sharing of microorganisms between people, thus favoring dysbiosis, which, in turn, may increase the poor prognosis of the disease. #covid #microbiome #dysbiosis Célia P. F. Domingues, João S. Rebelo, Francisco Dionisio, Ana Botelho, Teresa Nogueira. The Social Distancing Imposed To Contain COVID-19 Can Affect Our Microbiome: a Double-Edged Sword in Human Health. mSphere, 2020; 5 (5) DOI: 10.1128/mSphere.00716-20 https://msphere.asm.org/content/5/5/e00716-20
“Simply put, DNA is not your destiny, and SNPs are duds for disease prediction,” said David Wishart, professor in the University of Alberta’s Department of Biological Sciences and the Department of Computing Science and co-author on the study. “The vast majority of diseases, including many cancers, diabetes, and Alzheimer’s disease, have a genetic contribution of 5 to 10 per cent at best.”
#DNA #HEALTH #Disease
Jonas Patron, Arnau Serra-Cayuela, Beomsoo Han, Carin Li, David Scott Wishart. Assessing the performance of genome-wide association studies for predicting disease risk. PLOS ONE, 2019; 14 (12): e0220215 DOI: 10.1371/journal.pone.0220215
Modest Weight loss can lead to Diabetes Remission
The researchers found that 257 participants (30%) participants were in remission at five-year follow-up. People who achieved weight loss of 10% or more within the first five years after diagnosis were more than twice as likely to go into remission compared to people who maintained the same weight.
“We’ve known for some time now that it’s possible to send diabetes into remission using fairly drastic measures such as intensive weight loss programmes and extreme calorie restriction,” says Dr Hajira Dambha-Miller from the Department of Public Health and Primary Care.
H. Dambha‐Miller, A. J. Day, J. Strelitz, G. Irving, S. J. Griffin. Behaviour change, weight loss and remission of Type 2 diabetes: a community‐based prospective cohort study. Diabetic Medicine, 2019; DOI: 10.1111/dme.14122
#diabetes #remission #diet
Ginkgo Biloba may have potential in treating Type 2 Diabetes
The pancreatic beta cells of diabetic rats are reduced and insulin secretion is curtailed. After having Ginkgo biloba and magnetized water added to their diets, the mass of the pancreatic beta cells and the amount of insulin in these cells was shown to increase markedly, almost back to normal levels, particularly in the Ginkgo biloba-treated group, says Hetta.
Impact of Ginkgo biloba extract and magnetized water on the survival rate and functional capabilities of pancreatic β-cells in type 2 diabetic rat model. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2019; Volume 12: 1339 DOI: 10.2147/DMSO.S209856
#ginkgobiloba #magnetizedwater #diabetes
Low copper levels linked to fatter fat cells
In studies of mouse cells, researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.
Haojun Yang, Martina Ralle, Michael J. Wolfgang, Neha Dhawan, Jason L. Burkhead, Susana Rodriguez, Jack H. Kaplan, G. William Wong, Norman Haughey, Svetlana Lutsenko. Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. PLOS Biology, 2018; 16 (9): e2006519 DOI: 10.1371/journal.pbio.2006519
How much weightlifting is good for the Heart?
Lifting weights for less than an hour a week may reduce your risk for a heart attack or stroke by 40 to 70 percent, according to a new Iowa State University study. Spending more than an hour in the weight room did not yield any additional benefit, the researchers found.
Yanghui Liu, Duck-chul Lee, Yehua Li, Weicheng Zhu, Riquan Zhang, Xuemei Sui, Carl J. Lavie, Steven N. Blair. Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality. Medicine & Science in Sports & Exercise, 2018; 1 DOI: 10.1249/MSS.0000000000001822
Blood Sugar Lowered Dramatically with AMPK Raising Alanine
Type 2 diabetes is driven by many metabolic pathways, with some pathways driven by amino acids, the molecular building blocks for proteins. Scientists at Joslin Diabetes Center now have shown that one amino acid, alanine, may produce a short-term lowering of glucose levels by altering energy metabolism in the cell.
Yusuke Adachi, Ana Luisa De Sousa-Coelho, Ikue Harata, Charlie Aoun, Sandra Weimer, Xu Shi, Karina N. Gonzalez Herrera, Hirokazu Takahashi, Chris Doherty, Yasushi Noguchi, Laurie J. Goodyear, Marcia C. Haigis, Robert E. Gerszten, Mary-Elizabeth Patti. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Molecular Metabolism, 2018; DOI: 10.1016/j.molmet.2018.08.002
AMPK, TYPE 2 Diabetes, alanine, glucose, insulin, Adenosine monophosphate-activated protein kinase, energy, glucose tolerance, ala, Krebs cycle, diabetes,
Lentils significantly reduce blood glucose levels
Replacing half a serving of rice with lentils caused blood glucose to drop by up to 20 per cent. Replacing potatoes with lentils led to a 35-per-cent drop.
Dita Moravek, Alison M Duncan, Laura B VanderSluis, Sarah J Turkstra, Erica J Rogers, Jessica M Wilson, Aileen Hawke, D Dan Ramdath; Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial, The Journal of Nutrition, Volume 148, Issue 4, 1 April 2018, Pages 535–541, doi:10.1093/jn/nxy018
Lifespan greatly enhanced with Synbiotics
Scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic diseases associated with aging.
Susan Westfall, Nikita Lomis, Satya Prakash. Longevity extension in Drosophila through gut-brain communication. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-25382-z
Researchers have successfully created a novel biomaterial that can be seeded with insulin-producing beta cells. Implantation of the beta cell-seeded biomaterial reversed diabetes in a mouse model by effectively normalizing glucose levels and significantly increasing survival.
2008 Post for filing
Drinking chamomile tea may help fight complications of diabetes Journal of Agricultural and Food Chemistry
Drinking chamomile tea daily with meals may help prevent the complications of diabetes, which include loss of vision, nerve damage, and kidney damage, researchers in Japan and the United Kingdom are reporting.
The findings could lead to the development of a new chamomile-based drug for type 2 diabetes, which is at epidemic levels in this country and spreading worldwide, they note. Their study appears in the Sept. 10 issue of the ACS’ Journal of Agricultural and Food Chemistry, a bi-weekly publication.
In the new study, Atsushi Kato and colleagues point out that chamomile, also known as manzanilla, has been used for years as a medicinal cure-all to treat a variety of medical problems including stress, colds, and menstrual cramps. Scientists recently proposed that the herbal tea might also be beneficial for fighting diabetes, but the theory hasn’t been scientifically tested until now.
To find out, the researchers fed chamomile extract to a group of diabetic rats for 21 days and compared the results to a group of control animals on a normal diet. The chamomile-supplemented animals showed a significant decrease in blood glucose levels compared with the controls, they say. The extract also showed significant inhibition of both ALR2 enzymes and sorbitol, whose elevated levels are associated with increased diabetic complications, the scientists say. — MTS
ARTICLE #2 FOR IMMEDIATE RELEASE “Protective Effects of Dietary chamomile Tea on Diabetic Complications”
DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/jf8014365
CONTACT: Atsushi Kato University of Toyama Toyama, Japan Fax: 81 76 434 5155 Email: firstname.lastname@example.org
Editors Top Five:1. Mayo Clinic proceedings highlights research about cardiovascular benefits of omega-3 fatty acids 2. Weight loss more effective than intensive insulin therapy for type 2 diabetics 3. Extra vitamin D in early childhood cuts adult diabetes risk 4. What effect does melatonin have in colitis? 5. Only two per cent of paediatric drug trials reported using independent safety monitoring
In this Issue:
1. Study finds bacteria may reduce risk for kidney stones 2. Type 2 Diabetes May Be Caused by Intestinal Dysfunction 3. When the chips are down — soak them! 4. High levels of estrogen associated with breast cancer recurrence 5. U of I scientists aim to overcome allergic reactions to soy 6. UCLA study finds that broccoli may help boost the aging immune system 7. One small step for man, one giant leap for advertising 8. Curing addiction with cannabis medicines 9. New bacteria contaminate hairspray 10. Oregon study raises questions on synthetic progestins 11. Magnesium associated with lower risk for some strokes in male smokers 12. HPV vaccine reduces abnormal pap test results 13. Mayo Clinic proceedings highlights research about cardiovascular benefits of omega-3 fatty acids 14. Postoperative chemotherapy does not improve survival in gastric cancer patients 15. Weight loss more effective than intensive insulin therapy for type 2 diabetics 16. Study raises caution on new painkillers 17. Is a cup of tea really the answer to everything — even anthrax? 18. Killer fungus spells disaster for wheat 19. Fertility in developing countries: words into action 20. Extra vitamin D in early childhood cuts adult diabetes risk 21. Rodent study finds artificial butter chemical harmful to lungs 22. Study in Circulation Research details how diabetes drives atherosclerosis 23. Legal exposure to asbestos-like material linked to lung damage 25 years later 24. An anti-inflammatory response to the vegan diet 25. Foodborne outbreaks from leafy greens on rise 26. Solving the drug price crisis 27. New study: Pycnogenol improves memory in elderly 28. Pneumococcal disease rates down significantly post-vaccine 29. What effect does melatonin have in colitis? 30. Do bacterial combinations result in enhanced cytokine production? No! 31. Grape skin compound fights the complications of diabetes 32. Scientists successfully awaken sleeping stem cells 33. Only two per cent of paediatric drug trials reported using independent safety monitoring http://healthresearchreport.me/2008/03/19/26th-health-research-report-19-mar-2008-reconstruction/
Health Technology Research Synopsis
Health Research Report
26th Issue Date 19 MAR 2008
Compiled By Ralph Turchiano