Tag: Chemotherapy

Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy

Drosophila intestines provide ‘ready-made stem cell microenvironments’ that are ‘difficult-to-impossible’ to create in petri dishes, offering an unconventional screen that allows researchers to test drugs in vivo. Credit: University of Massachusetts Amherst                                          Using a new approach to systematically test chemotherapy drugs in an unusual animal model, […]

Neurotoxicity of chemotherapy drugs / triggers changes in ion channels on dorsal root ganglia and dorsal horn neurons

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research Chemotherapy is one of the primary treatments for cancer. However, one of the most disturbing findings of recent studies of cancer survivors is the apparent prevalence of chemotherapy-associated adverse neurological effects, including vascular complications, seizures, mood disorders, cognitive dysfunctions, and […]

Xenical and Alli, inhibits a key enzyme that may lead to “severe toxicity of internal organs such as the liver and kidney.” The inhibition is irreversible and can be caused by a low level of the drug.

Contact: Dave Lavallee dlavallee@advance.uri.edu 401-874-5862 University of Rhode Island Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies KINGSTON, R.I.— December 10, 2012 – A University of Rhode Island researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, […]

Bisphenol A linked to chemotherapy resistance

2008 study posted for filing Contact: Dama Kimmon dama.kimmon@uc.edu 513-558-4519 University of Cincinnati CINCINNATI—Exposure to bisphenol A (BPA) may reduce the effectiveness of chemotherapy treatments, say University of Cincinnati (UC) scientists. The research study, led by UC’s Nira Ben-Jonathan, PhD, says that BPA—a man-made chemical found in a […]

Researchers detail chemotherapy’s damage to the brain” Chemotherapy drugs used to treat a wide range of cancers were more toxic to healthy brain cells than the cancer cells they were intended to treat

Re-post from 2008: This is not the watered down Chemo brain article released 5 Sep 2012..4 years later contact: Mark Michaud mark_michaud@urmc.rochester.edu 585-273-4790 University of Rochester Medical Center A commonly used chemotherapy drug causes healthy brain cells to die off long after treatment has ended and may be […]

Anti-cancer ( Avastin ) drug damages brain vessels

Contact: Hema Bashyam hbashyam@rockefeller.edu 212-327-7053 Journal of Experimental Medicine The cancer drug Avastin (bevacizumab) is used to treat advanced bowel cancer in combination with chemotherapy. This drug targets a protein called VEGF (vascular endothelial growth factor) that stimulates blood vessel growth. Avastin inhibits the growth of tumors by […]

Cancer conflict with chemotherapy treatment – Chemotherapy gave no Survival advantage

Contact: Charlotte Webber press@biomedcentral.com 44-020-763-19980 BioMed Central Young women suffering from breast cancer do not necessarily benefit from chemotherapy treatment Women under the age of forty with breast cancer who are given drugs in addition to lumpectomies or radiotherapy, known as adjuvant chemotherapy, may not be benefiting from […]