COLITIS, Intestinal Bowel Disease greatly helped by Urolithin A

COLITIS, Intestinal Bowel Disease greatly helped by Urolithin A

Administration of these agents after mice have developed full colitis has reversed the phenotype significantly by reducing shortening of colons, gut permeability, and inflammation. When animals were fed with UroA or its synthetic analog prior to insulting with TNBS, mice did not develop colitis. Therefore, proving the protective nature of these compounds against gut inflammation. These results suggest that UroA/UAS03 mediated enhanced gut barrier function will likely have long-term beneficial effects in preventing colitis.

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

doi.org/10.1038/s41467-018-07859-7DO – 10.1038/s41467-018-07859-7ID – Singh2019ER

https://www.nature.com/articles/s41467-018-07859-7

Author: Ralph Turchiano

In short, I review clinical research on an almost daily basis. What I post tends to be articles that are relevant to the readers in addition to some curiosities that have intriguing potential. As a hobby, I truly enjoy the puzzle-solving play that statistics and programming as in the python language bring to the table. I just do not enjoy problem-solving, I love problem-solving and the childlike inspiration and exploration of that innocent exhilaration of discovering something new. Enjoy ;-)