NAC shown to help protect Osteoarthritis and Osteopenia

NAC shown to help protect Osteoarthritis and Osteopenia

NAC shown to help protect Osteoarthritis and Osteopenia

A protein involved in multiple cellular processes called ANP32A protects cartilage in the joints against degradation by damaging oxidation, preventing the development and progression of osteoarthritis, according to a new study by Frederique Cornelis and colleagues. Their findings suggest that some N-Acetyl Cysteine could be useful in preventing further cartilage damage and reducing the severity of osteoarthritis, and potentially other bone and brain disorders.

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

BY FREDERIQUE M. F. CORNELIS, SILVIA MONTEAGUDO, LAURA-AN K. A. GUNS, WOUTER DEN HOLLANDER, ROB G. H. H. NELISSEN, LIES STORMS, TINE PEETERS, ILSE JONKERS, INGRID MEULENBELT, RIK J. LORIES

Science Translational Medicine 12 Sep 2018: Vol. 10, Issue 458, eaar8426 DOI: 10.1126/scitranslmed.aar8426

NAC, N-Acetyl cysteine, osteoarthritis, osteopenia, ataxia, anp32a, atm, enzyme, brain disorders, bone loss, antioxidant