We are led to question whether the recommended social distancing measures to prevent SARS-CoV-2 transmission could increase the number of other serious instabilities. The breaking of the contagion pathways reduces the sharing of microorganisms between people, thus favoring dysbiosis, which, in turn, may increase the poor prognosis of the disease. #covid #microbiome #dysbiosis Célia P. F. Domingues, João S. Rebelo, Francisco Dionisio, Ana Botelho, Teresa Nogueira. The Social Distancing Imposed To Contain COVID-19 Can Affect Our Microbiome: a Double-Edged Sword in Human Health. mSphere, 2020; 5 (5) DOI: 10.1128/mSphere.00716-20 https://msphere.asm.org/content/5/5/e00716-20
2009 study posted for filing
Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology
New research published in the Journal of Leukocyte Biology finds retinoic acid may alleviate ulcerative colitis and similar irritable bowel diseases
Here’s another reason why you should take your vitamins. A new research report appearing in the October 2009 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) suggests that retinoic acid, the oxidized form of vitamin A, could be a beneficial treatment for people suffering from ulcerative colitis and other irritable bowel diseases. Specifically they found that retinoic acid helps suppress out-of-control inflammation, which is a hallmark of active ulcerative colitis.
“Pharmaceutical strategies based on this research may offer a promising alternative to our current approaches of managing immune diseases including, IBD, arthritis, multiple sclerosis, and so on,” Aiping Bai, a researcher involved in the work from Nanchang University in Nanchang City, China.
To make this discovery, Bai and colleagues conducted in vitro studies with human tissue and in vivo studies in mice. Both studies ultimately found that treatment with retinoic acid reduced the inflammation in the colon by increasing the expression of FOXP3, a gene involved with immune system responses, as well as decreasing the expression of IL-17, a cytokine believed to cause inflammation. Because many experts believe that IL-17 directly relates to the uncontrolled inflammation seen in ulcerative colitis and irritable bowel disease, the discovery that retinoic acid reduces IL-17’s ability to cause inflammation could accelerate the development of treatments for these chronic diseases.
“Runaway inflammation is serious problem, no matter where it occurs in the body, but in many instances, the root cause is a mystery,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “This research helps scientists better understand what causes and controls inflammation in the colon, which in turn, helps lay the groundwork for new classes of drugs to treat this devastating condition.”
The Journal of Leukocyte Biology (http://www.jleukbio.org) publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.
Details: Aiping Bai, Nonghua Lu, Yuan Guo, Zhanju Liu, Jiang Chen, and Zhikang Peng. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J Leukoc Biol 2009 86: 959� doi: doi:10.1189/jlb.0109006 ; http://www.jleukbio.org/cgi/content/abstract/86/4/959
Editors Top Five:
1. Optimal Dose of Vitamin E Maximizes Benefits, Minimizes Risk
2. Study shows pine bark reduces jetlag
3. Vitamin B3 reduces Alzheimer’s symptoms, lesions
4. The upside to allergies: cancer prevention
5. Can rectal vitamin E induce remission in patients with mild to moderate ulcerative colitis?
In this Issue:
1. Eating red meat sets up target for disease-causing bacteria
2. Grapes may aid a bunch of heart risk factors, animal study finds
3. The upside to allergies: cancer prevention
4. New MU Study Indicates that Exercise Prevents Fatty Liver Disease
5. Vigorous activity protects against breast cancer
6. Optimal Dose of Vitamin E Maximizes Benefits, Minimizes Risk
7. Drinking milk to ease milk allergy
8. Can rectal vitamin E induce remission in patients with mild to moderate ulcerative colitis?
9. How did glycine significantly decrease liver injury?
10. Fibromyalgia can no longer be called the ‘invisible’ syndrome
11. New evidence for homeopathy
12. Vitamin B3 reduces Alzheimer’s symptoms, lesions
13. Study shows pine bark reduces jetlag
14. Dietary sport supplement shows strong effects in the elderly
15. UC Davis researchers discover Achilles’ heel in pancreatic cancer
16. Could vitamin D save us from radiation?
17. LOW POTASSIUM LINKED TO HIGH BLOOD PRESSURE
18. Doctors should disclose off-label prescribing to their patients
19. Can vitamins and minerals prevent hearing loss?
Health Technology Research Synopsis
43rd Issue Date 11 NOV 2008
Compiled By Ralph Turchiano