Prebiotics may help activate anti-tumor immunity

Prebiotics may help activate anti-tumor immunity

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two prebiotics, mucin and inulin, slowed the growth of melanoma in mice by boosting the immune system’s ability to fight cancer. In contrast to probiotics, which are live bacterial strains, prebiotics are “food” for bacteria and stimulate the growth of diverse beneficial populations. The study, published today in Cell Reports, provides further evidence that gut microbes have a role in shaping the immune response to cancer, and supports efforts to target the gut microbiome to enhance the efficacy of cancer therapy.

#inulin #prebiotics #cancer

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li, Lisa Elme´ n, Igor Segota, Tao Long, Scott N. Peterson, Ze’ev A. Ronai

https://doi.org/10.1016/j.celrep.2020.01.035

https://www.sciencedirect.com/science/article/pii/S2211124720300504#app2

Copper nanoparticles and immunotherapy rapidly eliminate cancer cells – Pilot Study

Copper nanoparticles and immunotherapy rapidly eliminate cancer cells – Pilot Study

The combination of the nanoparticles and immunotherapy made the tumours disappear entirely and, as a result, works as a vaccine for lung and colon cancer – the two types that were investigated in the study. To confirm their finding, the researchers injected tumour cells back into the mice. These cells were immediately eliminated by the immune system, which was on the lookout for any new, similar, cells invading the body.

#copper #cancer #immunotherapy

Hendrik Naatz, Bella B. Manshian, Carla Rios Luci, Vasiliki Tsikourkitoudi, Yiannis Deligiannakis, Johannes Birkenstock, Suman Pokhrel, Lutz Mädler, Stefaan J. Soenen. Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications. Angewandte Chemie International Edition, 2020; DOI: 10.1002/anie.201912312

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912312

Aҫaí berry treated malaria with a 100% survival rate

Aҫaí berry treated malaria with a 100% survival rate

Aҫaí berry treated malaria with a 100% survival rate

All of the mice given polyphenols survived for more than 15 days, whereas none of the untreated mice lived. The aҫaí extracts appeared to interfere with the parasites’ protein homeostasis, or the balance between protein production and degradation, the researchers say.

Letícia T. Ferreira et al. Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Açaı́ (Euterpe oleracea Mart.) Polyphenols, ACS Omega (2019). DOI: 10.1021/acsomega.9b02127

#malaria #acai #treatment

https://pubs.acs.org/doi/10.1021/acsomega.9b02127

Acai, acai berry, Aҫaí berry, malaria, parasites, extract, cure, treat, survive, Polyphenols, pulp, total phenolic, chabaudi chabaudi, chloroquine-resistant, antimalarial drugs

Neuropathy Completely Reversed with monounsaturated fats

Neuropathy Completely Reversed with monounsaturated fats

Swapping dietary saturated fats for monounsaturated fats reverses nerve damage and restores nerve function in male mice, finds new preclinical research published in JNeurosci.

Amy E. Rumora, Giovanni LoGrasso, John M. Hayes, Faye E. Mendelson, Maegan A. Tabbey, Julia A. Haidar, Stephen I. Lentz, Eva L. Feldman. The divergent roles of dietary saturated and monounsaturated fatty acids on nerve function in murine models of obesity. The Journal of Neuroscience, 2019; 3173-18 DOI: 10.1523/JNEUROSCI.3173-18.2019

#nerve #neuropathy #monounsaturated

http://www.jneurosci.org/content/39/19/3770

Paralysis Reversed, neuroprosthetic rehabilitation (Animal Study)

Paralysis Reversed, neuroprosthetic rehabilitation (Animal Study)

Paralysis Reversed, neuroprosthetic rehabilitation (Animal Study)

The therapy triggers the growth of new connections from the motor cortex into the brain stem and from the brain stem into the spinal cord, thus reconnecting the brain with the spinal cord below the injury. — ” after just a few weeks of training, the rats regain extensive control over their hindlimbs – at will”

Citation: Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion, Nature Neuroscience (2018). nature.com/articles/doi:10.1038/s41593-018-0093-5