Common Herbicide May Devastate Future Generations

Common Herbicide May Devastate Future Generations

The study provides evidence that glyphosate-induced changes to exposed rats could be used as biomarkers for determining propensity in subsequent generations for prostate and kidney diseases as well as obesity and incurring multiple diseases at once. In fact, by the time third- and fourth-generation rats whose predecessors had been exposed to the chemical were middle-aged, 90% had one or more of these health problems, a dramatically higher rate than the control group.

Epigenome-wide association study for glyphosate induced transgenerational xxxxx DNA methylation and histone retention epigenetic biomarkers for disease

https://www.tandfonline.com/doi/full/10.1080/15592294.2020.1853319

#glyphosate #herbicide #epigenome

Glyphosate, herbicide, transgenerational, histone, DNA methylation, prostate, kidney, obesity, epigenetic transgenerational inheritance of pathology, toxicology, pesticide, organic, generation, diagnostic tests, germline epimutation, include imprinted-like gene characteristics

GM corn variety ‘cannot be regarded as safe’: Author of study linking food to cancer issues new attack

  • Study found rats eating GM corn NK603  suffered higher risk of tumours
  • Researchers hit back at critics who they  suggest are too close to industry

By  Lewis Smith

PUBLISHED: 07:12 EST, 21  November 2012 |  UPDATED: 10:51 EST, 21 November 2012

 

The team of researchers who caused uproar  when they claimed a variety of genetically modified corn causes cancer has  insisted the crop ‘cannot be regarded as safe’.

Leading scientists lined up to condemn the  study after it was published two months ago, saying it lacked scientific rigour  and had made a series of basic errors.

Russia banned the import of the corn and a  group of six French scientific institutions carried out an investigation which  accused the study authors of playing on public fears to hype their own  reputations.

Two GM corncobs (right) are compared to non-GM corn (left) grown in Germany.Just too perfect? Two GM corncobs (right) are compared  to non-GM corn (left) grown in Germany

 

But French scientist Dr Gilles-Eric  Séralini  and his colleagues have now hit back maintaining the safety  of the NK603  variety of GM corn remains unproven.

They accused many of their critics of lacking  credibility because of links to the GM industry and said much of the criticism  was led by ‘plant biologists, some developing patents on GMOs, and from Monsanto  Company owning these products’.

 

Refusing to give in to demands to withdraw  their study, they said their findings represented ‘the most detailed test’ of  genetically modified crops that are ‘ independent from the biotech and pesticide  companies’ which develop them.

They said in their rebuttal, published as a  letter to the journal Food and Chemical Toxicology, that unlike many other  scientists involved in researching GM foods they were free from industry  influence because they had no intention of ‘commercialising a new  product’.

It was also pointed out by the team that the  research represented a ‘first step’ rather than a final conclusion about the  potential impacts of NK603 corn and that further experiments may be able to  establish its safety.

For their original study they carried out  experiments on rats and concluded that the GM corn, developed by US biotech  company Monsanto, increased the risks of breast cancer and liver and kidney  damage.

GM crops biohazard warning. 

Controversial: The introduction of GM foods to our shops  has been met with horror by some consumers

Experiments carried out by the team also  suggested that tiny quantities of the widely available weedkiller Roundup, also  developed by Monsanto, was also associated with an increased risk of  cancer.

The experiments were carried out over two  years whereas, they pointed out, biotech companies have usually based claims  that their GM products are safe after feeding new varieties to rats for 90  days.

After publication of the study, in the peer  reviewed Food and Chemical Toxicology, a  dozen senior scientists signed a letter  to the journal saying  it should never have been published.

GM FOOD  REGULATION

GM food and feed is strictly regulated within the  EU.

Labels must indicate to consumers when GM  ingredients are included in food

All products that are GM or include GM ingredients  must meet traceability rules so that all retailers are able to identify their  suppliers.

Risk assessments for all new GM products are  carried out by the European Food Safety Authority before they can be sold in  Europe

‘This study does not provide sound evidence  to support its claims. Indeed, the flaws in the study are so obvious that the  paper should never have passed review,’ they wrote.

‘This appears to be a case of blatant  misrepresentation and misinterpretation of data to advance an anti-GMO agenda by  an investigator with a clear vested interest.’

The European Food Safety Authority (EFSA)  ordered a French University to carry out a review of the research while in  Russia the Institute of Nutrition was asked to conduct a similar  exercise.

Monsanto said in a statement in September:  ‘Based on our initial review, we do not believe the study presents information  that would justify any change in EFSA’s views on the safety of genetically  modified corn products or alter their approval status for genetically modified  imports.’

Read  the rebuttal by Dr Séraliniand  and his colleagues.

Read more: http://www.dailymail.co.uk/sciencetech/article-2236219/GM-corn-variety-regarded-safe-Dr-Gilles-Eric-S-ralini-hits-critics.html#ixzz2CwWWuJHb Follow us: @MailOnline on Twitter | DailyMail on Facebook

Environmental toxin Bisphenol A can affect newborn brain

Newborn mice that are exposed to Bisphenol A develop changes in their spontaneous behavior and evince poorer adaptation to new environments, as well hyperactivity as young adults. This has been shown by researchers at Uppsala University. Their study also revealed that one of the brain’s most important signal systems, the cholinergic signal system, is affected by Bisphenol A and that the effect persisted into adulthood.

Our environment contains a number of pollutants, including Bisphenol A, which is used in plastics in a number of different applications. When plastic products are used, Bisphenol A can leak out, which is especially problematic as it is used in baby bottles, tin cans, plastic containers, plastic mugs, which are used by people of all ages. Both in Sweden and globally, Bisphenol A is widely used, and the substance has been found in human placentas, fetuses, and breast milk.

In recent years measurable amounts of Bisphenol have been found in dust from regular homes, but opinion differs regarding any negative effects of Bisphenol A, and risk assessments from various parts of the world present contradictory recommendations, even though the information used comes from the same research reports. Here in Sweden the Swedish Chemicals Agency and the Medical Products Agency are working on a ban for Bisphenol A in baby bottles and certain other plastic products.

In humans and mammals, the brain develops intensively during a limited period of time. In human babies, this brain development period runs from the seventh month of gestation through the first two years of life. The corresponding period for mice takes place during the 3-4 first weeks after birth. Uppsala researchers have shown in previous research studies that various toxic compounds can induce permanent damage to brain function when they are administered to newborn mice during this developmental period. Examples of such compounds are so-called brominated flame-retardants, polychlorinated biphenyls (PCBs), and DDT.

In an entirely new study these researchers examined whether exposure to Bisphenol A during the neonatal period can cause permanent damage to brain function. In the experiment different doses of Bisphenol A were given to mice when they were ten days old. The mice underwent a so-called spontaneous behavior test as young adults, in which they were made to change cages from their well-known home cage to another identical one during one hour. Normal mice are very active during the first 20 minutes, exploring the new home environment. This activity declines during the next 20 minutes, and in the final 20 minutes it drops even more, and the mice settle down and sleep.

“In our study we found that a single exposure to Bisphenol A during the short critical period of brain development in the neonatal period leads to changes in spontaneous behavior and poorer adaptation to new environments, as well as hyperactivity among young adult mice. When this is examined again later in their adult life, these functional disturbances persist, which indicates that the damage is permanent and do not in fact disappear,” says Henrik Viberg at the Department of Organism Biology.

Using the same behavioral method, it was also examined whether the individuals that had received Bisphenol A during their neonatal period reacted differently than normal individuals to adult exposure to nicotine, which would indicate that one of the brain’s most important signal systems, the cholinergic signal system, was affected. Normal animals exposed as adults to the given dose of nicotine experience dramatically increased activity compared with animals that were not exposed to nicotine. Animals that had been exposed to Bisphenol A during their neonatal period and then received nicotine as adults did not evince the same hyperactivity as normal animals at all. This indicates that the choligernic signal system had been affected and that these individuals had had developed increased sensitivity to this type of exposure in adulthood. Once again, this effect was induced during the neonatal period but persisted into adulthood.

“We have previously seen this type of effect from several other environmental toxins that are still prevalent in both indoor and outdoor environments. As these effects are similar to each other, it’s possible that several different environmental toxins, including Bisphenol A, may work together in causing disturbances during brain development. This in turn may mean that the individual dosages of the various environmental toxins that are required to cause disturbances may be lower than those we examined in our studies of, for example, Bisphenol and brominated flame-retardants,” says Henrik Viberg.

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This research is published in the scientific journal Toxicology.

Dose-dependent behavioral disturbances after a single neonatal Bisphenol A dose, Toxicology, In Press, Uncorrected Proof, Henrik Viberg, Anders Fredriksson, Sonja Buratovic, Per Eriksson doi:10.1016/j.tox.2011.09.006

For more information please contact Henrik Viberg, tel: 46-18-471 7695; mobile: 46-70-171 9060, e-mail: henrik.viberg@ebc.uu.se