Researchers identify melatonin as a possible COVID-19 treatment

Analysis of patient data from Cleveland Clinic’s COVID-19 registry also revealed that melatonin usage was associated with a nearly 30 percent reduced likelihood of testing positive for SARS-CoV-2 (the virus that causes COVID-19) after adjusting for age, race, smoking history and various disease comorbidities. Notably, the reduced likelihood of testing positive for the virus increased from 30 to 52 percent for African Americans when adjusted for the same variables

#melatonin #covid19 #sarscov2

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000970#pbio-3000970-g007

Yadi Zhou, Yuan Hou, Jiayu Shen, Reena Mehra, Asha Kallianpur, Daniel A. Culver, Michaela U. Gack, Samar Farha, Joe Zein, Suzy Comhair, Claudio Fiocchi, Thaddeus Stappenbeck, Timothy Chan, Charis Eng, Jae U. Jung, Lara Jehi, Serpil Erzurum, Feixiong Cheng. A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLOS Biology, 2020; 18 (11): e3000970 DOI: 10.1371/journal.pbio.3000970

Honeysuckle Decoction Inhibits SARS-CoV-2

In a new study in Cell Discovery, Chen-Yu Zhang’s group at Nanjing University and two other groups from Wuhan Institute of Virology and the Second Hospital of Nanjing present a novel finding that absorbed miRNA MIR2911 in honeysuckle decoction (HD) can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking of HD accelerate the negative conversion of COVID-19 patients.

#mir2911 #sarcov2 #honeysuckle

Zhou, L., Zhou, Z., Jiang, X. et al. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. Cell Discov 6, 54 (2020). https://doi.org/10.1038/s41421-020-00197-3

https://www.nature.com/articles/s41421-020-00197-3#ethics

COVID-19 Infection and Mortality Rate Questions

COVID-19 Infection and Mortality Rate Questions

Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while the first patient was symptomatic. Despite active monitoring and testing of 372 contacts of both cases, no further transmission was detected

The RKI added: ‘We don’t consider post-mortem tests to be a decisive factor.

‘We work on the principle that patients are tested before they die.’

But this means that if a person dies in quarantine at home and does not go to hospital, there is a high chance they will not be included in the statistics, as Giovanni Maga of Italy’s National Research Council pointed out in an interview with Euronews

First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA. The Lancet, 2020; DOI: 10.1016/S0140-6736(20)30607-3

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30607-3/fulltext

COVID-19 and the Risk to Health Care Workers: A Case Report

Published: Ann Intern Med. 2020. DOI: 10.7326/L20-0175

https://annals.org/aim/fullarticle/2763329/covid-19-risk-health-care-workers-case-report

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