Dark Chocolate improves vision with 2 hours

Dark Chocolate improves vision with 2 hours   Contrast sensitivity and visual acuity were significantly higher 2 hours after consumption of a dark chocolate bar compared with a milk chocolate bar, but the duration of these effects and their influence in real-world performance await further testing. Rabin JC, Karunathilake N, Patrizi K. Effects of Milk…

FDA often ignored or just not there for many drug approvals and trials

Study examines FDA influence on design of pivotal drug studies An examination of the potential interaction between pharmaceutical companies and the U.S. Food and Drug Administration (FDA) to discuss future studies finds that one-quarter of recent new drug approvals occurred without any meeting, and when such meetings occurred, pharmaceutical companies did not comply with one-quarter…

Discrepancies between trial results reported on clinical trial registry and in journals ( nearly all had discrepancies )

– nearly all had at least 1 discrepancy in the study group – Our findings raise questions about accuracy of both ClinicalTrials.gov and publications, as each source’s reported results at times disagreed with the other. During a one year period, among clinical trials published in high-impact journals that reported results on a public clinical trial…

Ghostwritten articles overstate benefits of ( Prempro ) hormone replacement therapy and downplay harms

Public release date: 7-Sep-2010 HRR-Re-Posted at Request – analyzed dozens of ghostwritten reviews and commentaries published in medical journals and journal supplements that were used to promote unproven benefits and downplay harms of Prempro – The analysis revealed that DesignWrite was paid US$25,000 to ghostwrite articles reporting clinical trials, including four manuscripts on the HOPE…

Results from many large clinical trials are never published

Contact: Tom Hughes tahughes@unch.unc.edu 919-966-6047 University of North Carolina Health Care Non-publication is more common among industry-funded trials, study finds CHAPEL HILL, N.C. – A new analysis of 585 large, randomized clinical trials registered with ClinicalTrials.gov finds that 29 percent have not been published in scientific journals. In addition, nearly 78 percent of the unpublished…

Unpublished trial data ‘violates an ethical obligation’ to study participants, say researchers / 1 in 3 large clinicals not Published

Contact: Stephanie Burns sburns@bmj.com 44-020-738-36920 BMJ-British Medical Journal   Study finds almost 1 in 3 large clinical trials still not published 5 years after completion Almost one in three (29%) large clinical trials remain unpublished five years after completion. And of these, 78% have no results publicly available, finds a study published on bmj.com today.…

Current study shows: Important information on effects and side effects of drugs is missing in most publications

IQWiG: Reliable assessment of drugs is only possible on the basis of clinical study reports (CSRs) In 2012 researchers from the German Institute for Quality and Efficiency in Health Care (IQWiG) presented a study in the BMJ analysing information sources used in 16 health technology assessment (HTA) reports of drugs (“benefit assessments”). This study clearly…

Drugs now to be approved based on a educated guess that it will help the patient, not necessarily improved survival

U.S. drugmakers cheer ‘speed lane’ for breakthrough therapies Source: Reuters – Wed, 24 Jul 2013 11:53 PM Author: Reuters By Toni Clarke WASHINGTON, July 24 (Reuters) – A new regulatory pathway could shave years off the traditional drug approval process in the United States, according to some companies whose drugs have been given “breakthrough therapy”…