AKG may increase Lifespan and DRAMATICALLY Increase Healthy Years
Noting that some of the mice did experience moderate lifespan extension (the average was around 12%), measures of healthspan increased more than 40 percent. Lithgow says the goal is always to compress the time of disease and frailty. “The nightmare scenario has always been life extension with no reduction in disability. In this study, the treated middle-aged mice got healthier over time. Even the mice that died early saw improvements in their health, which was really surprising and encouraging.”
Citation: Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice DOI: 10.1016/j.cmet 2020.08.044
Declining eyesight improved by looking at deep red light
Staring at a deep red light for three minutes a day can significantly improve declining eyesight, finds a new study, the first of its kind in humans.
#vision #eyesight #redlight
Glen Jeffery, Magella Neveu, Victor Chong, Chris Hogg, Sobha Sivaprasad, Manjot Grewal, Harpreet Shinhmar. Optically improved mitochondrial function redeems aged human visual decline. The Journals of Gerontology: Series A, 2020; DOI: 10.1093/gerona/glaa155
Choline Supplementation and Alzheimer’s Prevention
Choline is an attractive candidate for prevention of AD as it is considered a very safe alternative, compared with many pharmaceuticals. “At 4.5 times the RDI (recommended daily intake), we are well under the tolerable upper limit, making this a safe preventive therapeutic strategy.”
#Alzheimer’s #prevention #choline
Ramon Velazquez, Eric Ferreira, Sara Knowles, Chaya Fux, Alexis Rodin, Wendy Winslow, Salvatore Oddo. Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell, 2019; DOI: 10.1111/acel.13037
Drinking tea improves brain structure, study suggests
A recent study led by researchers from the National University of Singapore (NUS) revealed that regular tea drinkers have better organised brain regions — and this is associated with healthy cognitive function — compared to non-tea drinkers. The research team made this discovery after examining neuroimaging data of 36 older adults.
Junhua Li, Rafael Romero-Garcia, John Suckling, Lei Feng. Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation. Aging, 2019; 11 (11): 3876 DOI: 10.18632/aging.102023
#tea #brainhealth #brainstructure
Cognitive decline reversed 30 years in 6 weeks
After just 1 ½ months, participants increased their cognitive abilities to levels similar to those of middle-aged adults, 30 years younger. Control group members, who did not take classes, showed no change in their performance. “The participants in the intervention bridged a 30 year difference in cognitive abilities after just 6 weeks and maintained these abilities while learning multiple new skills,” said Wu, who is an assistant professor of psychology
Shirley Leanos, Esra Kürüm, Carla M Strickland-Hughes, Annie S Ditta, Gianhu Nguyen, Miranda Felix, Hara Yum, George W Rebok, Rachel Wu. The Impact of Learning Multiple Real-World Skills on Cognitive Abilities and Functional Independence in Healthy Older Adults. The Journals of Gerontology: Series B, 2019; DOI: 10.1093/geronb/gbz084
#cognitive #episodic #reversal
Lifespan and Health Extended Dramatically with Fisetin
University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
#healthyaging, lifespan, fisetin
Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 2018; DOI: 10.1016/j.ebiom.2018.09.015
Aging reversed through mitochondrial DNA replenishment
Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial function is restored by turning off the gene responsible for mitochondrial dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.
Bhupendra Singh, Trenton R. Schoeb, Prachi Bajpai, Andrzej Slominski, Keshav K. Singh. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. Cell Death & Disease, 2018; 9 (7) DOI: 10.1038/s41419-018-0765-9
Lifespan greatly enhanced with Synbiotics
Scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic diseases associated with aging.
Susan Westfall, Nikita Lomis, Satya Prakash. Longevity extension in Drosophila through gut-brain communication. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-25382-z