Low copper levels linked to fatter fat cells

Low copper levels linked to fatter fat cells

Low copper levels linked to fatter fat cells

In studies of mouse cells, researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.

Haojun Yang, Martina Ralle, Michael J. Wolfgang, Neha Dhawan, Jason L. Burkhead, Susana Rodriguez, Jack H. Kaplan, G. William Wong, Norman Haughey, Svetlana Lutsenko. Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. PLOS Biology, 2018; 16 (9): e2006519 DOI: 10.1371/journal.pbio.2006519

 

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006519

Bone mineral density increased 4.8% in 12 months with MSDK

Bone mineral density increased 4.8% in 12 months with MSDK

Bone mineral density increased 4.8% in 12 months with MSDK

This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%)

Maria S, Swanson MH, Enderby LT, et al. Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures. Aging (Albany NY). 2017;9(1):256-285.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310667/